In 1861, Isabella became friends with Anna Dickinson, who was nineteen years old when she came to Hartford to speak on behalf of the Republican party, particularly on its hostility to the extension of slavery.  Isabella wrote, “It was certainly a most startling occurrence that here in my very home, where there had been hardly a lisp in favor of the rights of women, this girl should speak on political subjects and that, too, upon the invitation of the leaders of a great political party. Here was a stride, not a mere step; and a stride almost to final victory for the suppressed rights of women.”

Anna Dickinson expanded the whole philosophy of women’s suffrage and invited Isabella to her home near Boston where Isabella joined Mr.Garrison and others in issuing a call for a convention which Isabella attended and helped in formation of the New England Woman Suffrage.

In 1867, Frances Ellen Burr had introduced a bill to the Connecticut legislature to allow all women the right to vote, but it didn’t get passed by a narrow vote of 111 to 93.  Isabella became very interested and in 1868, she wrote ‘A Mother’s Letters to a Daughter on Woman's Suffrage’, which was published anonymously Putnam's Monthly.​​​​​​​

Photo - Isabella Hooker, 1873. Courtesy Harriet Beecher Stowe Center

Isabella was inspired by her older sister’s book and later Isabella wrote, "My sister's book, 'Uncle Tom's Cabin,' Which first appeared as a serial in an anti-slavery paper published in Washington, had such an influence in the abolition cause that it gave me an incentive to do the best I could to emancipate women.”

In 1969 Isabella organized  a state society of 'The Connecticut Woman Suffrage Association and Society for the Study of Political Science,' paying all the expenses of a two days' convention.

In 1870 she presented a bill to the  Connecticut Legislature making husband and wife equal in property rights and have persisted in its passage without avail.

In 1971, at her own expense, she organized a National Convention in Washington calling the attention of Congress to the fact that women were already citizens of the United States under the Constitution interpreted by the Declaration of Independence, and only needed recognition by that body to become voters.

Isabella Beecher fought to break the barriers to Gender Equality, dedicated her life’s work to women's suffrage movement and empowerment of women.  She helped to give Connecticut women property and marriage rights and helped to give all women of America the right to vote. Her passion for equality reshaped America, improved Women's Rights in the United States. Isabella Beecher Hooker is one of the heroes of Women's Suffrage in United States who made it possible passage of 19th Amendment to the Constitutions of United States granting women the right to vote.